Water-soluble azulene pharmaceutical

Abstract

PURPOSE: The titled pharmaceutical, prepared by incorporating a water-soluble azulene with polyvinylpyrrolidone, stable even under high temperature or high humidity conditions, and capable of keeping the initial potency of the water-soluble azulene for a long term. CONSTITUTION: A water-soluble azulene pharmaceutical prepared by incorporating one pts.wt. water-soluble azulene, having a noticeable antiallergic, antiinflammatory and tissue regenerating action, etc., and expressed by the formula with 0.1pts.wt. or more preferably 0.5W30pts.wt., polyvinylpyrrolidone. Both are dissolved in a solvent and adsorbed on a suitable excipient to give a complex of the both, which is then formulated into a pharmaceutical according to the conventional technique of formulating the pharmaceutical. The water-soluble azulene in the above-mentioned pharmaceutical has no sublimative property but very rich stability and is capable of keeping the initial potency almost intact even after the lapse of one year. COPYRIGHT: (C)1984,JPO&Japio

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    JP-S61151123-AJuly 09, 1986Sanwa Kagaku Kenkyusho:KkImmuno-regulator