Methods of evolutionary synthesis including embodied chemical syntheses

包括具体化学合成的进化合成方法

Abstract

本发明提供了一种用于制备化合物或产物的方法,所述化合物或产物具有满足或超出用户规范的一个或多个特征,所述工艺流程包括选择化学输入的第一组合的步骤,可选地和物理输入一起,并将那些输入供应给反应空间,从而生成第一产物;分析所生成的产物的一个或多个特征;将所述一个或多个特征与用户规范对比;使用遗传算法选择化学输入的第二组合,可选地与物理输入一起,其中所述第二组合不同于第一组合,并将那些输入供应给反应空间,从而生成第二产物;分析所生成的第二产物的一个或多个特征;将所生成的一个或多个特征与所述用户规范对比;对于化学和/或物理输入的进一步的单独组合重复选择和分析步骤,以提供产物阵列,其中,所述流动化学系统连续操作以提供第一、第二和进一步的产物,从而确定满足或超出用户规范的一种或多种产物。
The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analysing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analysing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analysing steps for further individual combinations of chemical and/or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.

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